NPR

When infectious pathogens have threatened the United States, the Centers for Disease Control and Prevention has been front and center. During the H1N1 flu of 2009, the Ebola crisis in 2014 and the mosquito-borne outbreak of Zika in 2015, the CDC has led the federal response.

So far, the coronavirus has hit hardest in wealthy countries. But the pandemic now appears poised to explode in many parts of the developing world — which has far fewer resources to combat the virus.

The virus initially traveled outward from China to places that had the most interaction with China. These are the richer parts of East Asia — South Korea, Japan, Taiwan, Singapore — along with Europe and the United States. All these places had lots of flights, business dealings and tourism with China.

A World Health Organization official says the evidence so far shows that the virus that causes COVID-19 is primarily transmitted through "respiratory droplets and contact routes" — from coughs and sneezes — and doesn't seem to linger in the air.

More than 1,200 people have now died of the coronavirus in New York, but the worst of the outbreak has yet to arrive, Gov. Andrew Cuomo said on Monday.

Cuomo said the coronavirus is overtaxing the state's health care workers. He asked for the assistance of medical volunteers from other parts of the country as the pandemic continues to devastate New York, the epicenter of the coronavirus outbreak in the United States.

Among the people whose lives are being turned upside down by the coronavirus are many pregnant women.

As they prepare for one of the most intense and emotional experiences of their lives, they face the possibility of delivering babies in hospitals filled with COVID-19 patients — and plans they've made for where to give birth and who will be there with them are often now in question.

Large numbers of companies are rolling out mandatory work-from-home policies to help limit the risks posed by the coronavirus outbreak. But cybersecurity experts warn that those remote setups invite new hacking risks.

The Federal Bureau of Investigation recently issued warnings of an uptick in fraudulent crimes tied to the coronavirus, particularly by scammers posing as official health agencies.

Two weeks ago, President Trump entered the White House briefing room and announced an aggressive plan to slow the spread of the coronavirus.

Stay home for 15 days, he told Americans. Avoid groups of more than 10 people. "If everyone makes this change, or these critical changes, and sacrifices now, we will rally together as one nation and we will defeat the virus," he said.

The nation's leading expert on infectious diseases and member of the White House's coronavirus task force says the pandemic could kill 100,000 to 200,000 Americans and infect millions.

Dr. Anthony Fauci said based on modeling of the current pace of the coronavirus' spread in the U.S., "between 100,000 and 200,000" people may die from COVID-19, the disease caused by the novel coronavirus.

The coronavirus appears to be much more lethal in some countries than in others.

In Italy, about 10% of people known to be infected have died. In Iran and Spain, the case fatality rate is higher than 7%. But in South Korea and the U.S. it's less than 1.5%. And in Germany, the figure is close to 0.5%.

So what gives?

The answer involves how many people are tested, the age of an infected population and factors such as whether the health care system is overwhelmed, scientists say.

Fast-moving viruses come with a cruel twist.

They tend to hammer hardest at people on the front lines of defense, making the rest of us that much more vulnerable.

Truckers, warehouse workers and cargo handlers, all in a vast network, find themselves one endless day after the next getting food, medicine and, yes, toilet paper to customers.

The complex supply logistics of our 21st-century world face a gathering storm even as reliance on those supply chains becomes more critical in the worst public health crisis in generations.

Over a thousand people in the U.S. have died from COVID-19, and over a third of those deaths have taken place in New York. Nearly half the confirmed cases in the United States are in New York.

The U.S. Senate's $2 trillion coronavirus relief package includes more than $30 billion for education, with more than $14 billion for colleges and universities and at least $13.5 billion for the nation's K-12 schools.

Updated 2:46 p.m. ET

Louisiana has emerged as a hot spot for the spread of coronavirus, with nearly 2,305 cases of COVID-19 and 83 reported deaths.

"Our rate of growth is faster than any state in the country," Democratic Gov. John Bel Edwards said during a televised address this week.

He warns the crisis has overwhelmed Louisiana's ability to combat the spread of the disease, and care for the sick. And in contrast to neighboring states, Louisiana is imposing tight restrictions on movement and economic activity.

Toilet tissue isn't the only paper product that Americans are hoarding these days. Paper money is also in high demand.

Banks are seeing more cash withdrawals as nervous customers try to protect themselves from the uncertainty of the coronavirus clampdown.

Updated at 10:51 a.m. ET

A record 3.28 million Americans filed for unemployment benefits last week as the coronavirus pandemic shut down much of the country. The Labor Department's report for the week ended March 21 was one of the first official indicators of how many people have suddenly been forced out of work nationally.

In the prior report, for the week ended March 14, initial claims totaled 282,000.

The Senate coronavirus relief bill now under consideration would give states $400 million to protect upcoming elections against the pandemic threat. The money, far less than the $4 billion some Democrats had wanted, would allow states to expand mail-in and early voting, as well as online voter registration. The money could also be used to help secure in-person voting sites.

As the new coronavirus continues to spread around the globe, researchers say the virus is changing its genetic makeup slightly. But does that mean it is becoming more dangerous to humans? And what would the impact be on any future vaccines?

At a time when the nation is desperate for authoritative information about the coronavirus pandemic, the country's foremost agency for fighting infectious disease outbreaks has gone conspicuously silent.

"I want to assure Americans that we have a team of public health experts," President Trump said at Tuesday evening's coronavirus task force briefing — a bit of reassurance that probably would not have been necessary if that briefing had included anyone from the Centers for Disease Control and Prevention.

As confirmed cases of the coronavirus in Germany soared past 10,000 last week, hundreds of Berliners crowded Volkspark am Friedrichshain to play soccer and basketball, and to let their kids loose on the park's many jungle gyms.

The conditions seemed ideal for the spread of a virus that has killed thousands. Indeed, as of Wednesday, Germany had the fifth-highest number of cases.

Yet Germany's fatality rate so far — just 0.5% — is the world's lowest, by a long shot.

Updated at 11:47 p.m. ET

The U.S. Senate overwhelmingly approved a $2 trillion relief package Wednesday night designed to alleviate some of the worst effects of the swift economic downturn currently underway as a result of the coronavirus pandemic.

Ahead of the 96-0 vote, Senate Majority Leader Mitch McConnell (R-Ky.) told lawmakers, "Our nation obviously is going through a kind of crisis that is totally unprecedented in living memory."

When Dr. Judy Salerno, who is in her 60s, got word that the New York State health department was looking for retired physicians to volunteer in the coronavirus crisis, she didn't hesitate.

"As I look to what's ahead for New York City, where I live, I'm thinking that if I can use my skills in some way that I will be helpful, I will step up," she says.

Across much of the nation, health care workers report ongoing, dire shortages of personal protective equipment (PPE) including hospital gowns, face shields and especially respiratory N95 face masks.

President Trump says key help is on the way from the strategic reserve and from private industry ramping up production, including big shipments from 3M.

In arguing for returning the country to some kind of normal sooner rather than later, President Trump noted that 36,000 people, on average, die from the flu each year.

"But we've never closed down the country for the flu," the president said during an appearance on Fox News on Tuesday. "So you say to yourself, 'What is this all about?' "

The rate of new coronavirus cases in New York is "doubling about every three days" and is speeding up even more, Gov. Andrew Cuomo said Tuesday. "That is a dramatic increase in the rate of infection."

The new estimates are "troubling and astronomical numbers," the governor said. He added that the apex of the curve of rising coronavirus cases in New York is still 14 to 21 days away, according to the latest projections. The governor also said New York is in urgent need of ventilators and other vital resources.